Psychedelia.dk

Hold nu. Du ødelægger ikke magien ved dit første MDMA trip, ved at tage så lille en allergitest. Hvis du googler hurtigt, vil du finde masser af folk som har fået allergiske reaktioner ved MDMA.
Jeg har heller aldrig mødt nogen, der var allergiske overfor Ketamin, men det kan man altså stadig godt være.
Men bare fordi du aldrig har hørt om det her på siden (som i forvejen er ret lille og har en ret lille brugerbase) så betyder det jo ikke at det ikke findes.

Guideline: your weight in kg, plus 50 = total dosage in milligrams for the session. (1.5 mg/kg with a 120 mg max may be more optimal, but the weight + 50 is a good rule of thumb). If you’re more cautious or want something a little less intense, perhaps weight in kg + 35-40.
https://rollsafe.org/mdma-dosage/

From MDMA researcher Matthew Baggott:

“I trained in an MDMA neurotoxicity lab (Lewis Seiden’s) and then went on to do human studies (giving MDMA to volunteers to understand its emotional effects). I think MDMA may well be neurotoxic at the higher end of recreational doses. I wouldn’t personally take/give more than 1.5-1.7 mg/kg and would never take/give a booster dose, unless there was strong reason to think the person would have some clear benefit (as in MDMA-assisted psychotherapy) to offset the added risks. Just my opinion.”

“To the best of my understanding, doses around 1.5-1.7 mg/kg MDMA (roughly 100 to 125 mg MDMA) are unlikely to cause long-lasting serotonin changes. Studies by MAPS have looked for changes in mental abilities after people participated in their studies, with some participants receiving 125 mg followed by 62.5 mg, and have not found any changes.”

“In studies such as this, we sometimes see bigger effects on heart rate than I would want and people frequently say they feel close to maximal effects. As a result, I tend to think 1.5 mg/kg is high enough and I would worry that 120 mg is too high for many smaller people.

I do agree there are limits to mg/kg scaling. Mg/kg is correcting for the volume in your body that the drug dissolves into, with the idea that people will get similar blood (and then brain) concentrations. However, this volume doesn’t scale with weight perfectly because peoples’ bodies are different on the high and low ends of weight. So I would personally suggest 1.5 mg/kg up to a maximum of 120 mg. I don’t have strong evidence for a minimal dose from my studies, but if forced to choose I might use a minimum dose of 75mg.

Interestingly, MAPS is seeing preliminary evidence that lower doses might be more therapeutic, which is consistent with observations by therapist Leo Zeff that people want higher doses than they need.”

“I would discourage total doses over 2 mg/kg MDMA.” (During the entire session/night, including re-doses)
https://rollsafe.org/mdma-dosage/
https://www.mdmawiki.org/wiki/Is_MDMA_Neurotoxic%3F

Nu har jeg ikke lige kilderne på det, men kan huske en bruger (basicreality?) pointerede at der ikke var den store sammenhæng mellem vægt og dosis, lige hvad angår mdma, kan desværre ikke lige huske hvem det var eller de links personen sendte mig.

30 mg senere, ingen allergisk reaktion eller effekt.

Tak for svarene allesammen!
Vil lige vurdere om jeg vil springe ud i 150 eller 100 mg

Det er ikke min erfaring overhovedet, igennem min psykonaut karriere, at der er nogen sammenligning mellem vægt og dosis, når man snakker psykedelika i helhed. Det er nærmere mere gældende når vi snakker MDMA, end de andre substancer.

Det er meningsløst at dosere Psilocybin, Ketamin, DMT og LSD udfra kropsvægt. På den anden side ville jeg nok ikke give en pige på 45kg, 150mg MDMA som startdosis.

Og jeg sørger for ikke at få for lidt, ved at veje mit stof og hellere tage for meget end for lidt, da jeg aldrig har taget skade af at tage 20mg ekstra. Men her er jeg lidt anderledes, end de fleste.

Men der har tolerance måske også noget at sige? Synes bare det er meget normalt at lige præcis med ketamin, så skal større folk have en større mængde. Dog er der jo også altid folk, som er mere sensitive overfor stoffet.