Psychedelia.dk

Hej, jeg har taget en MAOI (St. johns wort) i ca. 3 uger, og stoppede for 4 dage siden. jeg skal til en fest den 3. februar, hvor jeg har planlagt at tage en del Ritalin, men kom så til at tænke på om det havde nogen som helst konsekvenser? har læst et sted at man skal vente 2 uger før man må tage stimulanser, efter man har været på MAOI-medicin, og sådan som det står nu, er der kun 11 dage mellem mit MAOI-stop og mit Ritalin-brug til den der fest...

så mit spørgsmål lyder på: vil det være farligt for mig at tage ritalin, 11 dage efter MAOI indtagelse?

Jeg ville råde dig til at lade være. Ritalin og MAOI kan være livsfarligt at blande. Selvom der går noget tid mellem, er det alligevel ret længe du har taget en MAOI, så ikke sikkert det er ude af kroppen endnu.

Better safe than sorry.

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Penalties against possession of a drug should not be more damaging to an individual than the use of the drug itself.

-Jimmy Carter

Jeg må indrømme, at jeg var helt blank, da du skrev, at den urt skulle være en MAOI, da jeg mente at den fungerer mere som en SNRI, men der er noget om det. Her er en der stiller det samme spørgsmål på erowid (Q) og svaret følger (A):

Q: I have read that St. John's wort is a natural MAO inhibitor, although Erowid does not identify it as such. Is this herb a genuine MAOI? If so, does it produce negative interactions with psychedelics that can lead to serotonin syndrome--such as can happen when mixing a prescription MAOI with DXM or MDMA?

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A: Although early analysis indicated that St. John's Wort (Hypericum perforatum) is a MAOI,1 more recent research has shown this action to be extremely weak, and the herb's antidepressant effects can not be attributed to MAO inhibition.1 There have been no reported "adverse MAOI effects" from the combination of St. John's Wort with any of the foods or drugs commonly contraindicated when taking a MAOI. However, several chemicals found in St. John's Wort are known to activate five cytochrome P450 enzymes, and the body uses cytochrome P450 enzymes to break down most pharmaceuticals. There is strong evidence that it decreases drug levels in the blood with a number of medications, reducing their effectiveness, among other possible interactions.1

St. John's Wort's method of action on mood is still a mystery. It has been shown to increase serotonin levels, but this may be accomplished via a means that is more comparable to tricyclic antidepressants than to selective serotonin reuptake inhibitors. In any case, several herbal medical texts recommend that people avoid taking St. John's Wort in conjunction with an SSRI, due to concerns about causing serotonin syndrome. For this reason, it seems prudent to also avoid, or be extremely careful when taking, recreational drugs that strongly boost serotonin--such as MDMA, MDA, etc.--while taking St. John's Wort. Thanks for bringing up this important question!

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The punishment of desire, is the agony of unfulfillment.

Most of the physical world is unseen.

Tak for en yderst informativ post Apheus!

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Once you get locked into a serious drug collection, the tendency is to push it as hard as you can.
Gør dig selv en tjeneste, og lad være med at starte en samling.

Okay tak for svarene, men betyder det så, at det faktisk ikke er farligt at tage Ritalin til den der fest, fordi St johns faktisk slet ikke er en MAOI?
Og Ritalin, mig bekendt, øger jo ikke serotonin særligt meget..

I svaret anbefaler de, at man skal helst undgå det, eller være ekstremt forsigtig, hvis man gør det.

>Tak Rush og det samme til dig i andre tråde.

_________________
The punishment of desire, is the agony of unfulfillment.

Most of the physical world is unseen.