Psychedelia.dk

Jeg er lidt træt af at der har været 43 views, og alligevel ingen kommentar.
Jeg ved at der findes flere kloge hoveder herinde, som sikkert har viden inden for dette, eller i det mindste et input.

Dr. Phibes, hvor er du?

Gabapentin (Neurontin), 1–(aminomethyl) cyclohexane–acetic acid, is an anti–epileptic drug which was introduced in 1993 and was originally approved for the treatment of partial seizures with or without secondary generalization. Recently, however, reports have documented its efficacy in the treatment of various neuropathic pain states such as complex regional pain syndrome, deafferentation neuropathy of the face, postherpetic neuralgia, sciatic type pain, and HIV–related neuropathy.52 The effective dose range is 30–300 mg/kg (systemic) and >37.5 mg/kg (IT).48 Gabapentin is reportedly completely ineffective in altering threshold responses to acute nociceptive stimuli at doses up to 300 mg/kg.53–56 Presently the mechanism of action as either an anticonvulsant or an analgesic is unknown. The antinociceptive effects are likely to be due to actions within the spinal cord, because 1000 times the IT dose is required to produce equianalgesic effects when given intraperitoneally.53,57 Gabapentin binds to the alpha 2 delta calcium channel subunit.48 However, the relationship between binding at this site and the analgesic properties of gabapentin have not been determined. The NMDA receptor complex may be a potential spinal locus for neuropathic pain relief , but it has not been conclusively found that this is the major site of action.48 Gabapentin has a relatively benign side effect profile and is well tolerated if dosing proceeds in a gradually escalating manner. It has few if any drug interactions and is primarily renally excreted. Although expensive, it does not require the routine monitoring of blood chemistries and liver functions tests like carbamazepine and phenytoin. To date, little evidence suggests the efficacy of felbamate or lamotrogine in the treatment of neuropathic pain. Further investigation is necessary.

Det er pga dit nye avatar Khazim

Jeg ved det ikke, har personligt kun prøvet gabapentin for at more mig og ikke mere, men jeg er mere interesseret i hvorfor du vil vide det her ? har du selv neuropatiske smerter grundet sygdom, eller skade, og overvejer at selvmedicinere dig selv eller er du bare nysgerrig ?

Hvis man må spørge.. fandt lige det her ved en hurtig google søgning:


http://www.spineuniverse.com/conditions ... athic-pain

Som man kan læse har man vist ikke fundet ud af det endnu, måden stoffet virker på er ukendt, og det har der vist været noget snak om før herinde på psy, derfor tror jeg måske ikke du skal regne med nogen kan komme med et svar.