Psychedelia.dk

Hey psychedelia, er det dumt at tage nogle dololer og lidt i weekenderne og hygge sig på.
Burde man ikke bare restituere bedre og vær klar til endnu en god uge med træning?
Eller ødelægger det noget med testprodutionen eller proteinsyntensen?

På et sølvfad:

"Single opioid administration modifies gonadal steroids in both the CNS and plasma of male rats.Ceccarelli I, De Padova AM, Fiorenzani P, Massafra C, Aloisi AM.
Pain and Stress Neurophysiology Laboratory, Neuroscience and Applied Physiology Section, Department of Physiology, University of Siena, Via Aldo Moro, 2, 53100 Siena, Italy.

While morphine remains one of the most widely used opioids for the treatment of painful conditions, other opioids are also commonly employed. Because of the interactions between opioids and gonadal hormones, in particular opioid-induced hypogonadism, this study investigated the effects of widely used opioids on plasma testosterone and estradiol levels and brain testosterone levels in male rats. Animals were s.c. injected with two concentrations of morphine (5 or 10 mg/kg), fentanyl (0.05 or 0.1 mg/kg), tramadol (10 or 40 mg/kg), buprenorphine (0.05 or 0.1 mg/kg) or saline (0.7 ml/kg). Four or 24 h after treatment, the rats were deeply anesthetized to collect blood samples from the abdominal aorta and to perfuse the brains with saline. Plasma and brain hormone levels were measured by radioimmunoassay. In rats studied 4 h after treatment, all the opioids except tramadol 10 mg/kg decreased plasma testosterone in comparison with saline administration. At the same time, plasma estradiol levels were lower than control in the groups treated with the low doses of morphine, tramadol and buprenorphine, while estradiol remained at control levels in the other groups. Twenty-four hours after treatment, plasma testosterone levels were different (higher) than control in the animals treated with the low doses of morphine, fentanyl and buprenorphine. Estradiol was lower than control in the low dose groups, while the high doses did not produce any changes with respect to control. Four hours after treatment, brain testosterone was drastically decreased in all groups except buprenorphine, in which it remained at control levels. All groups returned to control levels at 24 h after treatment. In conclusion, opioids exert important effects on plasma and CNS sex hormone levels. The different magnitude and time-course of the effects of the different opiates on testosterone and estradiol levels are likely due to their different mechanism of action.

PMID: 16580783 [PubMed - indexed for MEDLINE]"

Og her et metastudie:

"Highlights
•Testosterone is suppressed by nearly 50% in opioid-using men.
•This suppression is not specific to methadone but to all opioids in general, whether it be for illicit or therapeutic use.
•Testosterone was not found to be suppressed in studies examining opioid-using women.
•Quality of literature in this field of study is poor.
Abstract
Background
Whether used for pain management or recreation, opioids have a number of adverse effects including hormonal imbalances. These imbalances have been reported to primarily involve testosterone and affect both males and females to the point of interfering with successful treatment and recovery. We conducted a systematic review and meta-analysis to determine the extent that opioids affect testosterone levels in both men and women, which may be relevant to improved treatment outcomes for opioid dependence and for pain management.

Methods
We searched PubMed, EMBASE, PsycINFO, and CINAHL for relevant articles and included studies that examined testosterone levels in men and women while on opioids. Data collection was completed in duplicate.

Results
Seventeen studies with 2769 participants (800 opioid users and 1969 controls) fulfilled the review inclusion criteria; 10 studies were cross-sectional and seven were cohort studies. Results showed a significant difference in mean testosterone level in men with opioid use compared to controls (MD = −164.78; 95% CI: −245.47, −84.08; p < 0.0001). Methadone did not affect testosterone differently than other opioids. Testosterone levels in women were not affected by opioids. Generalizability of results was limited due to high heterogeneity among studies and overall low quality of evidence.

Conclusions
Our findings demonstrated that testosterone level is suppressed in men with regular opioid use regardless of opioid type. We found that opioids affect testosterone levels differently in men than women. This suggests that opioids, including methadone, may have different endocrine disruption mechanisms in men and women, which should be considered when treating opioid dependence."

Det tog 30 sekunder at søge.

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Bagsidens gule sider - Giftlinjen, rådgivning om misbrug mm.

Men det påvirker testeroenen negativt ved regelmæssig brug, men går det ind under et weekend forbrug.
Det vil bedre end at smadre alt testproduktionen med alt fylde kroppen med alkohol

Spis din spinat og drop helt alkohol og stoffer hvis du er så bekymret for hvordan det vil påvirke din hormonproduktion.
Ellers så affind dig med at du vil være weekendkriger og så husk at spis rigeligt i weekenden.

_________________
Bagsidens gule sider - Giftlinjen, rådgivning om misbrug mm.