David Nutt from the University of Bristol proposes making an alcohol alternative that contains a GABA-A partial agonist. It would bind to a GABA-A receptor, but only partially activate it, triggering a weaker response. Because a partial agonist takes the place of a true agonist, it blocks the agonist from latching on to the receptor and causing the full effect.

In theory, an alcohol alternative could contain a chemical agent that would bind only to the receptors that affect the positive effects of drinking (relaxation, pleasure), but not to the receptors that affect the negative effects (nausea, memory loss). In other words, if you drink it, you'd still get a "buzz" without having some or all of the harmful effects of alcohol on your body. And when the body breaks down this alcohol alternative, it would not produce acetaldehyde, the toxic substance that leads to hangovers and other ill effects of drinking. And, if people drink too much of this alcohol alternative, they could take the benzodiazepine antidote flumazenil (brand name Annexate), which would instantly help them sober up so they could drive home. Flumazenil is sometimes used in hospital emergency rooms to awaken patients who are unconscious for no apparent reason.

Det er da allerede opfundet.. GHB

hvad er jeres mening. ville det være muligt at markedsføre GHB som tilsætning til nonalkoholiske øl og drikke? 0,5g som 1 genstand måske? så er der et stykke vej op til OD alligevel.

det var også det jeg kom frem til. et fandens dilemma er det. det er den tillærte uansvarlige omgang med alkohol, der forhindrer indførelsen af et uskadeligt alternativ. hele hele den sociale omgangsform omkring beruselse ville skulle omformes => not gonna happen!

Psysostigmin hed det vist, det skulle vække personen på få minutter i stedet for flere timer