En ny undersøgelse fra USA forbinder hashrygning med forhøjet risiko for at udvikle nonseminoma, den aggressive type testikelkræft.

Og Danmark har den højeste procent af testikelkræfttilfælde i verden.

Kan det tænkes at det er tobaksrygningen i sig selv, der forsager testikelkræften?
der er jo næsten ingen hashrygere der ikke blander med tobak, eller ryger smøger udover hashen.

Videnskab.dk skriver følgende:


Sørgeligt, sørgeligt, men én som jeg, der sjældent ryger hash kan da ikke være i farezonen?

Mon ikke de har korrigeret for det? Jeg kan næsten ikke forestille mig andet hvis de har publiceret artiklen i et seriøst tidsskrift.

Kan det tænkes at det er tobaksrygningen i sig selv, der forsager testikelkræften?
der er jo næsten ingen hashrygere der ikke blander med tobak, eller ryger smøger udover hashen.

I må undskylde hvis jeg lige bliver nødt til at blive pissesur, men hvorfor fanden er det så svært for folk at give ordentlige referencer? Hvad med et link til den oprindelige artikel? Eller bare ordentlig information om hvor man skal finde den? Jeg har ihvertfald ikke haft held med at finde frem til den og jeg kan derfor heller ikke tage den gang hø den mindste smule alvorligt.
Gud ved om journalisten (og for den sags skyld lægen) overhovedet selv har læst artiklen, eller om de bare går ud fra pressematerialet. Jeg synes det lyder lidt sådan.

Original Article
Association of marijuana use and the incidence of testicular germ cell tumors
Janet R. Daling, PhD 1 2 *, David R. Doody, MS 1, Xiaofei Sun, BS 3, Britton L. Trabert, MS, MSPH 1 2, Noel S. Weiss, MD, DrPH 1 2, Chu Chen, PhD 1 2, Mary L. Biggs, PhD 1 4, Jacqueline R. Starr, PhD 1 2 5, Sudhansu K. Dey, PhD 6, Stephen M. Schwartz, PhD 1 2
1Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington
2Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington
3Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee
4Department of Biostatistics, School of Public Health and Community Medicine, University of Washington, Seattle, Washington
5Department of Pediatrics, School of Medicine, University of Washington, Seattle, Washington
6Cincinnati Children's Research Foundation, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio

email: Janet R. Daling (jdaling@fhcrc.org)

*Correspondence to Janet R. Daling, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, PO Box 19024, Seattle, WA 98109

Fax: (206) 667-5948

Funded by:
National Institutes of Health; Grant Number: R01CA085914, NO1-PC-35142
Fred Hutchinson Cancer Research Center
National Institute on Drug Abuse; Grant Number: R37DA06668

Keywords
marijuana use • seminomas • nonseminomas • testicular tumors


Abstract

BACKGROUND:
The incidence of testicular germ cell tumors (TGCTs) has been increasing the past 4 to 6 decades; however, exposures that account for this rise have not been identified. Marijuana use also grew during the same period, and it has been established that chronic marijuana use produces adverse effects on the human endocrine and reproductive systems. In this study, the authors tested the hypothesis that marijuana use is a risk factor for TGCT.

METHODS:
A population-based, case-control study of 369 men ages 18 to 44 years who were diagnosed with TGCT from January 1999 through January 2006 was conducted in King, Pierce and Snohomish Counties in Washington State. The responses of these men to questions on their lifetime marijuana use were compared with the responses of 979 age-matched controls who resided in the same 3 counties during the case diagnosis period.

RESULTS:
Men with a TGCT were more likely to be current marijuana smokers at the reference date compared with controls (odds ratio [OR], 1.7; 95% confidence interval [95% CI], 1.1-2.5). In analyses according to histologic type, most of the association between current marijuana use and TGCT was observed in men who had nonseminomas/mixed histology tumors (current use: OR, 2.3; 95% CI, 1.3-4.0). Age at first use among current users (age <18 years [OR, 2.8] vs age 18 years [OR, 1.3]) and frequency of use (daily or weekly [OR, 3.0] vs less than once per week [OR, 1.8]) appeared to modify the risk.

CONCLUSIONS:
An association was observed between marijuana use and the occurrence of nonseminoma TGCTs. Additional studies of TGCTs will be needed to test this hypothesis, including molecular analyses of cannabinoid receptors and endocannabinoid signaling, which may provide clues regarding the biologic mechanisms of TGCTs. Cancer 2009. © 2009 American Cancer Society.



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Received: 4 August 2008; Revised: 29 September 2008; Accepted: 3 October 2008
Digital Object Identifier (DOI)

10.1002/cncr.24159 About DOI

Ved egentlig ikke hvad jeg skal tro på.

Har du svært ved at kende forskel på lunger og nosser?

Ikke for at sige det er smart at ryge pot, hvis man kan få testikkel cancer, men chancen er jo uendeligt lille om man ryger eller ej. Chancen for at få det uden at ryge er 1:300, chancen for at dø af det er 1:500. dvs. at hvis du ryger pot dagligt er din chance noget lignende 0,7%.

og de 0,7 procents canche der, hvordan er du kommet frem til dem ?