Findes som resoribletter, der lægges under tungen.

Når midlet tages normalt, har naloxon ingen effekt og der doseres efter indholdet af buprenorphin.

Should I "spit or swallow" (my Suboxone saliva?)

As stated above, the manufacturers of sublingual buprenorphine medications make it clear that taking the medication involves placing it under the tongue and allowing it to fully dissolve. There are no further instructions regarding the saliva left in the mouth after the pill or strip is dissolved and gone.

Therefore, spitting out the saliva or swallowing it should be an individual decision. My opinion is that spitting out the saliva is the best option if possible.

Spitting it out may reduce medication side effects. The reduction of buprenorphine induced constipation makes sense since spitting out the saliva may keep excess buprenorphine away from intestinal opioid receptors.

Also, the amount of medication to be absorbed has been calibrated by manufacturers such that everything that the patient is expected to get into their system will get in by allowing the tablet of film to dissolve under the tongue. There is no need to attempt to get every last bit by swallowing the saliva. And, swallowing saliva with a few micrograms of buprenorphine is not going to make any difference, since the drug is minimally active when swallowed.

(Buprenorphine has a half-life that ranges from 24 to 42 hours.)