25I-NBOMe is a relatively new substance, and little is known about its pharmacological risks or its interaction with other substances. The lethal dosage has not yet been determined.[4] PsychonautWiki advises that due to 25I-NBOMe extreme potency it should not be insufflated as this method of administration appears to have led to several deaths in the past year.[5]

This substance came to media attention in early 2012 after a cluster of seven non-fatal overdoses with the drug were reported in or around Richmond, Virginia.[6][7] As of May 2013, 25I-NBOMe has reportedly led to five overdose deaths in the United States.[8] In June 2012, two teens in Grand Forks, North Dakota and East Grand Forks, Minnesota fatally overdosed on a substance that was allegedly 25I-NBOMe, resulting in lengthy sentences for two of the parties involved and a Federal indictment against the Texas based online vendor.[8]