I would be very cautious with this combo, personally. This is not the same as methylone + ketamine; methoxetamine is a DARI and a D2 partial agonist, among a slew of other things (it most likely has a broad binding profile: NMDA antagonist, (partial?) mu agonist, sigma agonist, K+ channel blocker, NACh antagonist, etc etc and who knows what, what I'm saying is that its not so easy to predict the safety of combinations with MXE).

My instinct seems to tell me that methoxetamine's dopaminergic pharmacology might be more similar to PCP than to ketamine. I obviously don't have any data to back that up, as MXE is unstudied, but its just a feeling I have. Anyways, given how cracked-out and dopamine fueled methylone can be-- especially after redosing-- I would honestly be pretty hesitant to combine it with MXE.

So methylone causes release of dopamine into the synaptic cleft and methoxetamine prevents reuptake of this dopamine back into the presynaptic nerve terminal. I can think of two things that happen:
- one is that you might 'spend' less dopamine, in this situation a little goes a longer way right?
- another is that it could much more easily be too much, it is more unpredictable and potentially more toxic, overstimulation side-effects as well as cardiovascular problems may occur.

I would personally say the second is not worth the first and I'd avoid it. Methoxetamine seems bad combined with any dopaminergic compound.

edit: apparently serotonergic ones are also not a smart idea though I have read about lots of people who liked it. Doesn't make it safe though!

Slap af MXE lyder som et drug der kan give nogen crazy bivirkninger.

RC junglen er risky business..