"'Lisuride (.....) was synthesized by Zikan and Semonsky (Zikan, V., M. Semonsky: Coll. Czech. Chem. Commun. (1960), 1922) in order to develop an LSD-25 analog with antiserotonin and antihistamine properties without having hallucinogenic side effects. (.....)

In one of the first clinical trials, Vojtechovsky et al (Activ. Nerv. Super. 5 (1963), 211) found in about half of the cases a moderate inhibitive dysphoric effect, while in about one third they found a slight central nervous system (CNS) effect without autonomous symptoms. In half of the subjects, however, the changes were so slight that they could not be distinguished from placebo. Lisuride did not alter the mental functions in psychological tests. (.....)'

The article also points out that lisuride can be effective against migraines as well as neurasthenia.

Incredible potential? A 'moderate inhibitive dysphoric effect' or a 'slight central nervous system effect' doesn't sound all that fancy to me. As a standalone drug, I think lisuride has only limited use."