Årh, for pokker, umiddelbart er der ingen hurtige veje ... Og det er kun blevet sværere over de senere år, hvor kommunerne har strammet så meget op, at antallet der visiteres til døgnbehandling er faldet fra 1400 til 700 årligt. MEN der er sat et forsøgsprojekt i gang, et Akut Krisecenter for stofafhængige, der dog kun omfatter udsatte, eventuelt livstruede, stofafhængige fra ca. 10 kommuner. Jeg kan derfor ikke sige, om det kan lade sig gøre, før jeg ved, hvilken kommune han tilhører (og jeg ER selvfølgelig gået i krig med ministrene på dette spørgsmål! Det er jo diskrimination så det basker, at det ikke er den akutte krise der afgør om man kan få hjælp, men ens postnummer! Sygt!). Kan du finde ud af hvilken kommune der er tale om? Kh Nanna

Vil ikke på den lukkede. du sidder i kigger ind i en hvid mur. og så kommer der en læge og snakker med dig i 15 minutter en gang om dagen.?

Substance dependence

Methylphenidate has shown some benefits as a replacement therapy for individuals dependent on methamphetamine.[52] Cocaine and methamphetamine block the protein DAT, over time causing DAT upregulation and lower cytoplasmic dopamine levels in their absence. Methylphenidate and amphetamine have been investigated as a chemical replacement for the treatment of cocaine dependence[53][54][55][56] in the same way that methadone is used as a replacement for heroin. Its effectiveness in treatment of cocaine or other psychostimulant dependence has not been proven and further research is needed.[57]

Early research began in 2007–2008[citation needed] in some countries[which?] on the effectiveness of methylphenidate as a substitute agent in refractory cases of cocaine dependence, owing to methylphenidate's longer half life, and reduced vasoconstrictive effects.[58][59] This replacement therapy is used in other classes of drugs such as opiates for maintenance and gradual withdrawal such as methadone, suboxone, etc.

once MDPV takes hold, it doesn't seem to let go.

“This is why people who abuse the drug feel the effects the next day,” she says.

Why MDPV causes such a prolonged response is central to this research, and De Felice has a theory. If you look at the chemical structure of MDPV, it has one structural feature that the other molecules don't: a short carbon chain with a methyl group at the end.

“It's got this little arm that sticks out,” he explains. “I think it's kind of like a fish hook. I think it goes in and it doesn't come out. That may be what makes it different than cocaine. It gets stuck in the transporter, and it holds it closed.

This could explain the strange behavior among abusers of these drugs, De Felice said. In fact, he thinks ingesting bath salts is akin to knocking out the dopamine transporters altogether.

"Eventually the body will replace them, presumably," he said. "But for hours and hours, you've essentially removed the dopamine transporters. So you've really messed up the whole balance of neurotransmitters in the brain."

The new studies both show that MDPV blocks all three transporters with much more potent effects at the DAT and NET relative to SERT. As Baumann and colleagues note, MDPV is 50 and 10 times more potent than cocaine (not an amphetamine, we'll come to this) at DAT and NET respectively. Simmler and colleagues similarly indicate that MDPV is much more potent at DAT than cocaine or methamphetamine which did not qualitatively differ from each other.