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Coconut husks and pumice combined in equal portions seem to be the best growing medium for Peyote, however seeds can be started in leaf mold, a blend of “Supersoil”, washed sand and perlite, or commercial cactus blend potting soil.
Peyote prefers a soil pH of 6.5-7.2. A more alkaline soil binds certain nutrients. Some of the healthiest Peyote I’ve seen was grown in leaf mold which tends to be acid. One soil mixture recommended to me is a blend of 5 parts “Supersoil” (a commercial blend), three parts washed sand, and three parts perlite (or pumice). The other mixture, a choice of commercial cactus growers mentioned earlier is 50% coconut husk and 50% pumice. An excellent additive recently added to Peyote Way gardens, is pyroclay, which is a natural fungicide, and also contains trace minerals essential to healthy plant growth.