I Harald Nielsen bog om giftplanter står der under hestekastanjen, at hvis man spiser den grønne skal udenom kastanjen fører det til mave-tarm kaktar,
pupiludvidelse,
synsforstyrrelse,
sindsforvirring og til sidst falder man i søvn af mathed.
Lyder ikke sindsygt ubehageligt, udover selvfølgelig mave-tarm kataren. Selve kastanjerne, barken og frøskallen indeholder aescin, som er et saponin, der er virksomt mod hæmorider og desuden er en 5-HT og histamin antagonist.
Citat:
Aescin: pharmacology, pharmacokinetics and therapeutic profile
Cesare R. Sirtori1
Department of Pharmacological Sciences, University of Milano, Via Balzaretti 9, 20133 Milano, Italy
Accepted 21 May 2001. ; Available online 26 February 2002.
Abstract
Aescin, the major active principle from Aesculus hippocastanum (Hippocastanaceae) the horse chestnut tree, has shown satisfactory evidence for a clinically significant activity in chronic venous insufficiency (CVI), haemorrhoids and post-operative oedema. In one controlled trial aescin was shown to be as effective as compression therapy as an alternative to medical treatment for CVI. The therapeutic benefit is well supported by a number of experimental investigations in different animal models, indicative of clearcut anti-oedematous, anti-inflammatory and venotonic properties, mainly related to the molecular mechanism of the agent, allowing improved entry of ions into channels, thus raising venous tension in both in vitro and in vivo conditions. Other mechanisms, i.e. release of PGF2from veins, antagonism to 5-HT and histamine, reduced catabolism of tissue mucopolysaccharides, further underline the wide ranging mechanisms of the therapeutic activity of aescin. The excellent tolerability of aescin in the clinic indicates this treatment is of definite clinical benefit in patients with clinical conditions resulting in CVI, haemorrhoids or peripheral oedema formation.
Author Keywords: aescin, horse chestnut, chronic venous insufficiency, haemorrhoids, post-operative oedema, review
1
cesare.sirtori@unimi.it Er der nogen af jer, der kan huske om i åd eller gnaskede på kastanjer da i var små? Hvis, ja, havde det så nogen effekt?
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