A Canadian study published in 2012 analysed Finola hemp and found that the flowers contained CBDA (the acidic precursor to CBD) at an approximately 2.4% concentration, while the leaves, stems and roots contained 0.5%, 0.04% and 0.004% respectively. The various parts also contained the precursor to CBDA, a substance known as hexanoyl-CoA, in concentrations of 15.5%, 4.0%, 2.2% and 1.5% respectively. Studies into high-THC varieties are apparently not available, but it is likely that the roots would also exhibit much lower concentrations than the flowers and leaves.

While cannabis roots no doubt possess various useful and important medicinal properties, it is important to note that in high doses it can cause hepatotoxicity, due to the presence of the alkaloids pyrrolidine and piperidine. It is also reported that the alkaloid content can irritate the stomach lining; thus, oral consumption of hemp-root tea is potentially riskier than topical application. Pyrrolidine and piperidine can also act as irritants of the skin, mucous membranes and lungs. It is unlikely that the compounds are present in high enough concentrations to present serious risk, but care should be taken to avoid prolonged or heavy use.